IMEC is a world-leading independent research center in nanoelectronics and nanotechnology. Main research areas include CMOS-based nanoelectronics, nanotechnology and post-CMOS electronics, bioelectronics and design technologies. IMEC’s research bridges the gap between fundamental research at universities and technology development in industry with its unique balance of processing system know-how, IP portfolio, state-of-the-art infrastructure and strong network of companies, universities and research institutes. The infrastructure relevant for this project includes: a cleanroom, a bio-electronics (including cell & tissue culture facilities), biochemical and characterization laboratories. The bioelectronic systems group in which this project will be carried out consists of a multidisciplinary team of engineers, (bio)chemists and physicists. Several researchers belonging to this research team would be involved in the activities involved in this project.

Tasks in the project
The main tasks of IMEC will be the surface functionalization for biosensing applications. IMEC will also contribute to the failure mode and effect analysis (FMEA), to the setting-up of new/relevant test, reliability and failure analysis methods and to the testing

Relevant Publications

F. Frederix, K. Bonroy, W. Laureyn, G. Reekmans, A. Campitelli, W. Dehaen and G. Maes, ‘Enhanced performance of an affinity biosensor interface based on mixed self-assembled monolayers of thiols on gold’, Langmuir 2003, 19(10), 4351
R. De Palma, W. Laureyn, F. Frederix, K. Bonroy, et al., ‘Formation of dense self-assembled monolayers of (n-decyl)trichlorosilanes on Ta/Ta2O5’, Langmuir, 2007, 23 (2), 443
R. De Palma, J. Trekker, S. Peeters, M. J. Van Bael, K. Bonroy, et al., ‘Surface modification of g- Fe2O3@SiO2 magnetic nanoparticles for the controlled interaction with biomolecules’, Journal of Nanoscience and Nanotechnology, in press S. Kalicinski, H. A.C. Tilmans, M. Wevers, I. De Wolf, A new method to determine the mechanical resonance frequency, quality factor and charging in electrostatically actuated MEMS. Accepted for MEMS 2008
De Wolf I.. Reliability of MEMS. Invited paper, Proc. EuroSimE2006
De Wolf I. “Spectroscopic techniques for MEMS inspection” in the book “Optical inspection of Microsystems”, Ed. W. Osten, Taylor & Francis, 2006.

Senior staff

Ingrid De Wolf received the MS degree in Physics and the PhD in Sciences, Physics, both from the KU Leuven. 1989 she joined the Reliability group of the Interuniversity MicroElectronics Center (IMEC). She worked in the field of reliability physics of semiconductor devices, with special attention for mechanical stress aspects and failure analysis. Since 1999, she heads the group REMO (Reliability and Modelling), where research is focused on Reliability and Modelling of MEMS, MEMS-packaging and IC- interconnect and packaging. She authored or co-authored in these fields several book chapters and more than 200 publications in international scientific journals and in international conference proceedings. She is IEEE and EDFAS member. She is also professor at the Metals and Applied Materials engineering department of the KU Leuven.
Prof. Liesbet Lagae obtained her PhD from University of Leuven in the field of nanomagnetism in 2003 After graduation she moved into the field of nanoelectronics based biosensors, where she became groupleader of the functional nanosystems in 2006. Her group consists of a multidisciplinary team of engineers, (bio)chemists, physicists, biomedical engineers, etc., all focusing on the use of nanoelectronics, nanotechnology and (bio)chemistry for the realization of novel biomolecular sensor systems and biochips. In 2007, she became associate professor in nanotechnological biophysics at the KULeuven/Physics department. She has participated and coordinated several biosensor related FP5, FP6 and FP7 EU projects from which FP6-CF-chip, FP6-Smarthealth and FP6-Mascot are the most relevant ones for this project.
Dr. Silvia Armini is a scientist who achieved her degree in physical chemistry with maximum score from Perugia's University followed by a specialization master in material science and microelectronics from Pavia's University. She obtained her PhD from KU Leuven in 2007, with the congratulations of the doctoral committee. She specialised in basic and applied experimental research on exploratory materials for nanoelectronic applications. She has extensive experience with state-of-the-art material characterisation techniques with a particular interest in spectroscopy. She has over 30 peer reviewed publications, a patent, and co-authored over 30 International Conference contributions.